Bioactive Placenta Peptides help reduce anxiety
In this test, mice were orally administered with control (purified water) or Bioactive Placenta Peptides. Their emotional behavior was evaluated 1 hour later with automatic hole-board test for 5 minutes.
Apparatus for hole-board test
Oral administration of Bioactive Placenta Peptides significantly increased the number and length of head-dip, indicating anti-anxiety effects of the placenta extract.
Bioactive Placenta Peptides help reduce stress
Rats administered with Bioactive Placenta Peptides showed an increased production of metallothionein (MT), an anti-stress protein.
The anti-stress effects of Bioactive Placenta Peptides were demonstrated in another test, in which the mice were induced electric stress and their emotional behavior was evaluated using an elevated plus maze. In this test, placenta extract or control (purified water) was orally administered to mice and they were subjected to electric stress after 50 minutes. The number of entries into the open arm and the duration of stay were evaluated as an anti-stress action, in which increment in both parameters indicates less stress.
Apparatus for elevated plus maze
Both parameters were significantly lower in control group. For Bioactive Placenta Peptides group, number of entries into the open arm decreased to a lesser extent, while there was no change of duration of stay compared to those not subjected to electric stress, indicating the anti-stress effects of
Bioactive Placenta Peptides help suppress prostate enlargement
Prostate enlargement is a condition associated with ageing and is common is men over 50 years old. The symptoms of prostate enlargement include dribbling urine, frequent urination, inability to urinate or pain or burning during urination. Higher testosterone (male sex hormone) levels may be a prime culprit for prostate enlargement.
In this study, testosterone was administered to castrated (removed testis) and the weight of prostate was compared for Bioactive Placenta Peptides and control (non-administration) groups. Compared to control group, prostate weight was reduced by approximately 15% for the Bioactive Placenta Peptides group, showing that the Bioactive Placenta Peptides could suppress prostate enlargement.
Bioactive Placenta Peptides help suppress proliferation of prostate cancer cells
Male sex hormone dihydrotestosterone (DHT) stimulates proliferation of prostate cancer cells. Hence, lowering DHT levels generally makes prostate cancer cells to shrink or grow more slowly. When placenta extract was added to the human prostate cancer cells in culture media without DHT, the cell count was not affected. For culture media with DHT, cell count was decreased in a dose-dependent manner. This suggests that Bioactive Placenta Peptides have DHT suppression effects, resulting in inhibition of proliferation of human prostate cancer cells.
Vitality, Stamina and Endurance:
Fatigue is a state of mental and physical weakness accompanied by a feeling of sleepiness, irritability and weariness. It can affect the quality of life and disturb daily routines.
Bioactive Placenta Peptides help fight fatigue from physical activity
In this study, mice were forced to swim for 60 minutes, which were then suspended on a thin nylon string with both arms hanging on it. Compared to control (purified water), the mice orally administered with Bioactive Placenta Peptides (1,670mg/kg) showed 30% longer duration of suspension, implying the anti-fatigue effects of the extract.
Bioactive Placenta Peptides mitigate protein-energy malnutrition-induced fatigue
Fatigue can be caused by a deficiency of nutrition or immune function. Bioactive Placenta Peptide and its constituents regulate protein-energy malnutrition-induced fatigue through improving levels of immunity and decreasing fatigue-related factors. Hence, Bioactive Placenta Peptides may be a potential agent for a recovery from fatigue.
Han et al. Nutrition. 2013 Nov-Dec;29(11-12):1381-7
Bioactive Placenta Peptides support healthy hair growth
Study 1: Dermal papilla is a highly active group of cells, which play a crucial role in hair growth cycle by inducing follicle development from the skin to grow a hair. In this study, proliferation effect of Bioactive Placenta Peptides were confirmed by using human hair follicle dermal papilla cells and the cell count was measured to evaluate cell proliferation. Bioactive Placenta Peptides increased proliferation of the cells in a dose-dependent manner, indicating its hair growth-promoting effects.
Study 2: Bioactive Placenta Peptides markedly improved hair length, number and diameter of hair follicles (HF) compared to control group. Besides, Bioactive Placenta Peptides may shorten the hair growth cycle.
Bioactive Placenta Peptides help increase depth and size of hair follicles
Bioactive Placenta Peptides (B) markedly increased the depth and size of hair follicles, as compared with that of control (C).
Healthy Joints & Muscles:
Rheumatoid arthritis is an autoimmune disorder which causes painful and swelling in joints. Bioactive Placenta Peptides have an anti-inflammatory function, which suppresses an abnormal immune system to relieve the pain of rheumatoid.
Bioactive Placenta Peptides reduce join pain and swelling
CRP (C-reactive protein) and RF (rheumatoid factor) are used as indices for rheumatoid arthritis. CRP is a specific protein which appears at sites of inflammation and RF is an antibody directed against the body’s own tissue. Data shows that Bioactive Placenta Peptides reduced CRP and RF over a relatively short period.
Gout is commonly caused by high levels of uric acid in the blood. Bioactive Placenta Peptides were shown to reduce the concentration of uric acid, suggesting its efficacy in mitigating gout conditions.
Bioactive Placenta Peptides protect against alcohol-induced liver dysfunction
Elevated liver enzymes [alanine transaminase (ALT) and aspartate transaminase (AST)] may indicate inflammation or damage to cells in the liver. Inflamed or injured liver cells leak higher than normal amounts of certain chemicals, including liver enzymes into the bloodstream, which can result in elevated liver enzymes on blood tests.
In this test, male mice were induced alcoholic hepatopathy (liver dysfunction) by administering ethanol (5g/kg) 3 times at 12-hour intervals. The amount of ALT and AST in blood was measured as an indicator of liver dysfunction. Bioactive Placenta Peptides suppressed the AST increment due to alcohol to a level that is similar to the group not treated with alcohol. Besides, Bioactive Placenta Peptides also suppressed ALT value by approximately 30% compared to control (purified water). The results suggest that Bioactive Placenta Peptides could help reduce alcohol-induced liver dysfunction.
Bioactive Placenta Peptides support liver regeneration
In this test, liver regeneration capability was evaluated by monitoring the wet weight of liver from remnant with 70% partial hepatectomy (surgical removal of liver). At 7 days after surgery, the wet weight of the remnant liver of the Bioactive Placenta Peptides-injected group reached nearly 100%, compared with the untreated group of about 85%. This suggests that Bioactive Placenta Peptides have beneficial effects on liver regeneration.
Blood Circulation & Heart Health:
Bioactive Placenta Peptides support healthy blood pressure
Angiotensin converting enzyme (ACE) is an enzyme that converts angiotensin I into angiotensin II, a powerful vasoconstrictor that causes the narrowing of the blood vessels and elevation of blood pressure. Hence, blocking ACE action could help mitigate high blood pressure. Bioactive Placenta Peptides were shown to suppress ACE, suggesting its beneficial effects in reducing elevated blood pressure.
Bioactive Placenta Peptides help improve memory and learning ability
Amnesia is a decline in memory caused temporarily by the use of various sedatives and sleep-inducing drugs. In this test, mice subjected to drug-induced amnesia were administered control (saline solution) or Bioactive Placenta Peptides. Bioactive Placenta Peptides significantly suppressed the decrease of the spontaneous alteration behavior rate resulting from the drug treatment. This suggests that Bioactive Placenta Peptides help improve memory and learning ability which may be affected by drugs.
Bioactive Placenta Peptides support healthy respiratory system
Nitric oxide (NO) is produced throughout the body, including in the lungs, to combat inflammation and relax tight muscles. High levels of exhaled NO in the breath can indicated the airways are inflamed — one sign of asthma. Asthma causes periods of coughing, wheezing, shortness of breath and chest tightness.
Compared to control (purified water), Bioactive Placenta Peptides reduced NO concentration in the lings. This suggests that Bioactive Placenta Peptides have inhibitory effects on airway inflammation.